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Since 2007, we've funded more than 250 cancer projects, including some exceptionally talented scientists and brilliant researchers. The result? We've funded 18 significant cancer breakthroughs in research and care.
Thanks to you, we're helping Australians to live happier, healthier and longer lives. Thank you.
Cancer evolution is the single biggest challenge we face in creating better treatment for those affected. Although there have been some incredible advances in the fight against cancer, the disease is constantly evolving and finding new ways to resist the effects of therapy. That's why we're incredibly proud of the projects we've funded and what we've achieved so far. It's spurred us on to achieve even greater things.
1. Professor Michelle Haber and Dr Glenn Marshall - http://tourdecure.com.au/pages/news/latest-stories/ccia-in-the-lancet
Children's cancer (paediatric cancer) - This article details the recent, highly successful works of the CCIA in translating research and technologies on several cancer types into viable treatments for children's afflicted by cancer. All of these successes were realised through collaboration with the 'Kid's Cancer Centre' (KCC).
2. Dr. Charles Bailey - http://www.cell.com/cell/abstract/S0092-8674%2813%2900834-9
Gene therapy - Normal white blood cells make use of a molecular ‘trash can’ to control many aspects of our body’s cellular defences. Over a hundred thousand white blood cells are produced in everyone’s body per second and their maturation must be carefully controlled. This article unveiled how commonly occurring stretches of DNA that interrupt genes (known as introns) play a crucial role in controlling gene expression.
Glioblastoma - This article explores ways to target the protein 'EphA3' which is found in large amounts in aggressive, adult Glioblastoma (a highly invasive Brain Cancer) and negatively affects survival rates. Therapies targeting this molecule significantly slow tumour progression. The information revealed in this research will improve survival rates in the future for many adult patients facing a Glioblastoma diagnosis.
4. Christopher J Chan - http://www.nature.com/cdd/journal/v21/n1/full/cdd201326a.html
6. Christopher J Chan - http://cancerdiscovery.aacrjournals.org/content/3/1/82.short
7. Christopher J Chan - http://www.nature.com/ni/journal/v13/n12/full/ni.2468.html
8. Christopher J Chan - http://www.sciencemag.org/content/337/6102/1678
9. Christopher J Chan - http://www.ncbi.nlm.nih.gov/pubmed/22285893
10. Christopher J Chan - http://www.jimmunol.org/content/185/11/6679.short
11. Christopher J Chan - http://www.jimmunol.org/content/184/2/902.short
Cellular reactions - Researcher Christopher J. Chan's work in the field of immunology has led to 8 Cancer research breakthroughs. The articles explore in-depth how the human body's immune system reacts to the threat of cancer on a cellular level . Knowing the body's immuno-response to cancer cells will undoubtedly informing the development of more effective cancer treatments.
12. Garvan Institute of Medical Research -http://www.ncbi.nlm.nih.gov/pubmed/24393131
Ovarian cancer - This study focused on the protein ZNF300P1 and it's behaviour/functions within Ovarian Cancer tissue. The findings revealed that it plays an important role in regulating key cell cycles and cell motility networks in human ovarian surface epithelial cells. It also may play a role in promoting metastasis in ovarian cancer cells.
13. Dr Tracy Putocki and Dr Chen Chen Jiang - http://ac.els-cdn.com/S1535610813003164/1-s2.0-S1535610813003164-main.pdf?_tid=7a3b1354-28ca-11e4-aae3-00000aab0f27&acdnat=1408581262_8455ad6c3c1719eb8e5c9e9e155796e4
Gastrointestinal cancers - In their exploration of the cytokin IL-11, these researchers exposed a potential target for future cancer treatments that will assist in the suppression of human gastrointestinal tumours.
Cellular Stress Responses - In response to hazardous agents, cells activate a range of complicated signalling pathways. These so-called cellular stress responses are pivotal for tumour suppression and also the success of radio- and chemotherapy. The EBook features 12 articles on cellular stress responses (review papers as well as original research articles presenting new findings) written by leading scientists in the field.
15. Dr Daniel Speidel - http://link.springer.com/article/10.1007%2Fs00204-015-1459-z
Tumour Suppression - The tumour suppressor p53 is a central player in cellular DNA damage responses and one of the most extensively studied genes in cancer research. In this review, Dr Speidel summarizes current knowledge on p53-controlled DNA damage responses, commenting also on recent controversially discussed findings.
16. Dr Daniel Speidel - http://www.nature.com/cddis/journal/v6/n6/full/cddis2015149a.html
Tumour Suppression - In this paper they describe a completely unexpected function of a protein that many cancers produce in abnormally high levels. Although previously described as cancer-promoting they report that depending on the exact circumstances the same protein can also enhance tumour suppression.
17. Dr Daniel Speidel - http://hmg.oxfordjournals.org/content/early/2015/08/12/hmg.ddv298.long
18. Murdoch Children's Research Institute - http://onlinelibrary.wiley.com/doi/10.1111/ppe.12193/full