Disrupting DNA Architecture in the nucleus

    NAME Dr Chuck Bailey
    CANCER TYPE 213
    INSTITUTION 229
    STATE New South Wales
    GRANT TYPE Other
    PROJECT TYPE Research

    Disrupting DNA Architecture in the nucleus: a new mechanism of cancer cell death. The DNA/Protein network that orchestrates genomic architecture and gene expression in the cell nucleus is coordinated by a protein called CTFC. We have designed small molecules that specifically inhibit this network leading to rapid cell death. Using this knowledge we can develop new therapeutics to kill cancer cells.