NAME Dr Chuck Bailey
CANCER TYPE 213
INSTITUTION 229
STATE New South Wales
GRANT TYPE Other
PROJECT TYPE Research

Disrupting DNA Architecture in the nucleus: a new mechanism of cancer cell death. The DNA/Protein network that orchestrates genomic architecture and gene expression in the cell nucleus is coordinated by a protein called CTFC. We have designed small molecules that specifically inhibit this network leading to rapid cell death. Using this knowledge we can develop new therapeutics to kill cancer cells.