The first targeted therapy against a newly discovered very aggressive subtype of neuroblastoma

    NAME A/Prof. Tao Liu
    CANCER TYPE Neuroblastoma
    INSTITUTION University of New South Wales
    STATE New South Wales
    GRANT TYPE $200,000
    PROJECT TYPE Research

    The first targeted therapy against a newly discovered very aggressive subtype of neuroblastoma

    "We aim to demonstrate that combination therapy with OTX015 and Carfilzomib synergistically induces tumour cell death, tumour shrinkage and regression in mice xenografted with TERT oncogene-rearranged neuroblastoma cells or patient-derived neuroblastoma tissues, with no toxicity to normal cells...Once the clinical trials are successful, the combination therapy will become the first ever targeted therapy for patients with neuroblastoma due to TERT oncogene rearrangement, leading to better survival rates and better quality of life."

    - A/Prof. Tao Liu, University of New South Wales